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the AGE-RAGE signaling, which induces axonal atrophy through p38 MAPK activation (Sango et al., 2025), and the PKC- activation, which impairs nerve blood flow via endothelin-1 overexpression ( Hyperglycemia-induced mitochondrial dysfunction in neuronal and Schwann cells leads to excessive O 2 production at complex I and III of the ETC, which initiates a cascade of injury through four primary mechanisms (Wu L

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Wan X, Vomund AN, Peterson OJ, Chervonsky AV, Lichti CF, Unanue ER (2020) The MHCII peptidome of the pancreatic islet identifies key features of autoimmune peptides

166,167 Most of these reports discussed the construction and characterization of CD-AuNPs

J Inherit Metab Dis 42:1019-1029