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Cozzi, A

Immune tolerance mechanisms, including central tolerance in the thymus and peripheral tolerance in secondary lymphoid organs, are essential for preventing autoimmunity [139, 140]

Am J Psychiatry 161:217222

According to the FDA's press release it agreed to approve the drug for obesity based on three randomised, double-blind, placebo-controlled trials during which more than 2,600 patients received Wegovy for up to 68 weeks and more than 1,500 patients received placebo (US FDA 2021)