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encouragingly, initial human case series now describe resumed menses and successful oocyte retrieval after autologous MSC grafting [169]

Enhanced autophagy is evidenced by increased expression of Beclin1, autophagy-related 5 (Atg-5)-Atg12, and LC3 in kidney tissue in UUO [22]

Second, crossing Jnk1 LoxP/LoxP / Jnk2 -/- mice with Alb-Cre mice deletes Jnk1 in hepatocytes during embryogenesis, raising the possibility of compensatory gene induction that could interfere with the final outcome