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The intrinsic MOMP-associated apoptotic pathway is tightly regulated by the Bcl-2 family of proteins comprising anti-apoptotic Bcl-2, Bcl-XL, Bcl-W, pro-apoptotic effector Bax and Bak proteins, and BH3-only proteins, including Bad, Bim, PUMA, and Bid (modulating apoptosis through antagonizing anti-apoptotic Bcl-2 or inducing the activity of Bax or Bak) [80, 259, 260]