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38,46 PK modeling simulations suggest that coadministration of a single dose of oral naloxegol (25 mg) with efavirenz (400 mg once daily), a moderate CYP3A inducer, results in naloxegol exposure that is similar to that after a 12.5-mg dose of naloxegol alone

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Finally, -butyrobetaine hydroxylase catalyzes the hydroxylation of - N -trimethylaminobutyrate to generate L-carnitine, requiring Fe 2+ and ascorbate

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