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While numerous questions can be asked in the context of glutamine metabolism and TB pathogenesis, a solid first step could be investigating the impact of Mtb upon the metabolic profiles of the immune cells and using the knowledge to block glutamine metabolism mindfully and selectively

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Also, in vitro studies indicate that the responsiveness of pro-B cells to IL-7 is compromised in aged individuals [355], and IL-7 release from stromal cells in the bone marrow also declines with age [356], leading to reduced pro B-cell proliferation