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Reproductive development of male rats exposed in utero to stress and/or sertraline

We next explored the broader metabolic impact of 5FU in these drug-tolerant cells

More importantly, comparable levels are maintained for at least 4 months that suggests these adaptive responses are established early and can be maintained for extended periods of time

Excessive ROS levels have been shown to cause dysbiosis of the gut microbiota by changing microbial composition, damaging epithelial barrier function and disrupting metabolic pathways (Li T

These higher research doses established safety margins while demonstrating therapeutic efficacy