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After treatment with the standard drugs - bisphosphonates or Selective Estrogen Receptor Modulators (SERMs) for 2 years, these values had returned to the levels determined in control subjects, accompanied by a significant improvement in measurements of bone density ( Both the mechanism and the pathological significance of this remain unclear

Effects on methoxychlor metabolism

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However, oxidative stress triggers the dissociation of Nrf2 from Keap1, allowing Nrf2 to translocate into the nucleus