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Nootropics, often called "smart drugs" or "cognitive enhancers," are substances that enhance brain function

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TDP-43 pathological changes in early onset Familial and sporadic Alzheimers disease, late onset Alzheimers disease and Downs syndrome: association with age, hippocampal sclerosis and clinical phenotype

Second, excess intracellular iron is sequestered by cytosolic ferritin, and can be dynamically released upon iron depletion via ferritinophagy 139,140