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Future research should verify the efficacy of these novel methods through large-scale, multi-center, randomized, double-blind, and long-term follow-up RCTs, while utilizing multi-omics and big data technologies to delve into their mechanisms of action, ultimately achieving the goal of comprehensive treatment based on microbiome-based precision regulation

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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]

Although the two countries have reached a peace agreement in principle, the process is ongoing and they are presently engaged in fully demarcating the border