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Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity

The activation of the intrinsic pathway is achieved by blocking antioxidant enzymes like GPX4

Consider complementary nutrients such as vitamin C and selenium that support glutathione recycling [2]

Disruption of this homeostatic equilibrium can lead to dysbiosis and consequent metabolic perturbations that are increasingly implicated in the pathogenesis of chronic conditions such as cancer, cardiometabolic disorders, and IBD (187)

This is an essential step that allows subsequently applied serums and creams to penetrate more easily and work more effectively