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Am J Physiol 1997

Whether using stool-based testing, colonoscopy, or emerging screening technologies, early detection dramatically improves outcomes

135 Further, PRAS40 and mTOR also exerts negative feedbacks on proximal insulin signaling, PRAS40 knockdown significantly decreases Akt phosphorylation, mTORC1 binds and inhibits INSR by inducing destabilization of IRS1