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The fat-soluble derivative Benfotiamine can be a more effective form for addressing depletion

13 Diagnosing a Hypermobility Spectrum Disorder (HSD) The diagnosis of a hypermobility spectrum disorder is used for those with symptomatic joint hypermobility, who do not meet the criteria for a diagnosis of hypermobile Ehlers Danlos Syndrome or other heritable or acquired (rheumatological or through injury) connective tissue disorders

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Specific genes such as SLITRK1 and DLGAP3 (SAPAP3) have been implicated, though the disorder is polygenic and shaped by environment and stress as well

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