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This finding was first well established in women who are heterozygous for hypoxanthine phosphoribosyltransferase deficiency, and it has also been observed in several women heterozygous for severely deficient G6PD variants

The biomarker approach requires analytical evaluation of (poly)phenol metabolites in biofluids to essentially reverse-trace a (poly)phenol from its end-stage metabolites towards its precursor and subsequently to its sources in food (Reference Scalbert, Brennan and Manach19)