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Heparanase activates the syndecan-syntenin-ALIX exosome pathway

2017;2:e92634

Interestingly, triptolide is found to enhance the sensitivity of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in pancreatic cancer cells by autophagy activation through Pumilio RNA-binding family member 1 (PUM1) downregulation, suggesting a potential strategy to increase tumor sensitivity to TRAIL [995]

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