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As TRAIL-expressing astrocytes have been previously demonstrated to induce T-cell apoptosis and downstream CNS inflammation, notably, the expression of this receptor was dependent on meningeal IFN expression from NK cells, and the microbiota was known to induce IFN expression from NK cells (Sanmarco et al., 2021)

Moreover, L-theanine also inhibited the transcription of MMP9 and Snail through weakening the ERK/NF-B signaling pathway and p65 binding activity with MMP9 and Snail promoter region (70)

Most side effects are mild and go away in a few days

Y.HuangM.et al (2020)

That asymmetry does not make the comparison worthless