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According to previous research, the Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) can restore mitochondrial function in hyperosmotic models of corneal epithelial cells, alleviating dry eye symptoms [18, 19]

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Cristofano A, et al

The expressions of fibrosis markers TGF-, CTGF, and Smad 2/3 were significantly up-regulated in the BCNI group

Duzel A, Vlainic J, Antunovic M, et al.: Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights