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In addition, a trend toward delayed progression to kidney failure and the need for dialysis was observed in the probiotic group compared with the placebo group at a 3-year follow-up

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doi: 10.1186/scrt27

These mechanisms include the synthesis and regulation of neurotransmitters, immune modulation, maintenance of the BBB, effects on neural development, interactions with neurotransmitter receptors, and associations with the neuroendocrine system