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Zhang and Marconi, 2005)

Metabolic reprogramming mtDNA mutations have emerged as potent regulators of cancer metabolic reprogramming, influencing not only mitochondrial respiration but also glycolysis, amino acid and lipid metabolism, lactate production [192]

Additionally, chrysin exhibited anti-tumor activity against choriocarcinoma cells through modification of mitochondrial membrane potential, disruption of Ca 2+ levels in cytosol, enhancing generation of reactive oxygen species (ROS), and inducing lipid peroxidation, which affects intracellular Ca 2+ homeostasis resulting in cancer cell damage [86]

Production of cAMP can also elicit postprandial-like insulin secretion by accelerating the glucose-dependent closure of ATP-regulated potassium channels (7779)