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10.1371/journal.pone.0112629 57 GranatoM.RizzelloC.Gilardini MontaniM

Yes, it may enhance endurance, reduce fatigue, and improve overall exercise performance when used consistently

Korean J.Nutrition 2007;40(7):630-638

Glucarpidase (Voraxaze), a bacterial enzyme that cleaves methotrexate to form inactive metabolites, was FDA approved in 2012 for the treatment of toxic methotrexate concentrations caused by impaired kidney clearance