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10.1007/s00415-020-09723-5 296 LubomskiM.XuX.HolmesA

While early-stage localized melanoma is often curable through surgical resection (Tyrell et al., 2017), the prognosis for metastatic melanoma remains poor, with distant metastatic cases exhibiting a 5-year survival rate of less than one-third (Tao et al., 2025), underscoring the complexity of clinical management