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Saudi Pharm J 26:876885

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doi: 10.1038/s41586-019-1707-0 86 MishimaEItoJWuZNakamuraTWahidaADollSet al

[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Silymarin in treatment of non-alcoholic steatohepatitis: a randomized clinical trial

Another study in 2019 indicated that NIN reduced -SMA and Smad3 protein and mRNA levels and blocked oxidative stress, inflammation and the TGF--Smad3 and JNK-Smad3 pathways, thereby carrying out its antifibrotic effects (Hernndez-Aquino et al., 2019)