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You will see it stated confidently in a lot of places that the body adapts after 4 to 6 weeks, tolerance builds, and the effect fades, so you have to cycle. It sounds authoritative

Ipamorelin and CJC-1295: Synergistic Growth Hormone Secretagogues Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist

Lee and colleagues demonstrated that MOTS-C administration prevents diet-induced obesity and insulin resistance in mouse models (Lee et al., Cell Metabolism 2015

B12 deficiency can cause a false menopause - as can being hypothyroid

Men with uncontrolled diabetes, insulin resistance, or metabolic disease should be evaluated carefully before starting peptides, since some peptides may affect appetite, blood sugar, insulin sensitivity, or fluid balance