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Induction of phase II detoxifying enzymes Many isothiocyanates are potent inducers of phase II detoxifying enzymes, including GSTs, UDP-glucuronosyl transferases (UGTs), NQO1, and glutamate cysteine ligase (GCL), that protect cells from DNA damage by carcinogens and reactive oxygen species (ROS) (25)

These results expand our understanding of FBI-1 and provide a solid foundation for a new strategy based on iron death for the treatment of CRPC

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[DOI] [PubMed] [Google Scholar] 86.Muir A, Danai LV, Gui DY, Waingarten CY, Lewis CA, Vander Heiden MG: Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition