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Han-Xiang, D

Mechanistically, this shift from beneficial to detrimental involves sustained activation of NF-B and p38 MAPK pathways, elevated ROS production from dysfunctional mitochondria, and unresolved DNA damage response signaling

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Conclusion: MT in the late window shows comparable effectiveness and safety to early treatment for primary MCA M2 occlusions in routine practice

doi:10.1016/j.jad.2011.06.005 Bhagwagar Z, Wylezinska M, Jezzard P, Evans J, Boorman E, Matthews PM, Cowen PJ (2008) Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients