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To determine whether crystal packing causes distinct L1 conformations, we analysed the loop-based symmetry contacts of each L1 shown in Fig

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NM_002084.3), in which the codons for Cys-12 (TGC), Cys-81 (TGC) and Cys-136 (TGT) were replaced with the codons for Ser (TCG) and the codon for Sec-53 (TGA) was changed to Cys codon (TGC)

Collectively, ferroptosis might be a sensor in response to the pathophysiological alterations that disrupt the iron, ROS and inflammation homeostasis of our cardiovascular system