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90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression

Folgueira, M

The concomitant treatment regimens also need adequate consideration

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GPX4 is the only cellular enzyme that specifically reduces phospholipid hydroperoxides to lipid alcohols using GSH as a co-factor 4 , and inhibiting the cyst(e)ine/GSH/GPX4 axis induces the strongest cell death in most cellular contexts