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The two main challenges of the technique are: (1) the need of a pulsed laser (with tens/hundreds ps duration) with high temporal coherence 15,16

However, certain special situations, such as immature blood-brain barrier (BBB) in infants, compromised BBB, high-dose exposure, small molecular weight, few aromatic amino acids, light hydrophobicity, light cationic properties, transport mechanisms, and indirect effects, can affect BBB transitions (Domenger et al

This means that old bone is removed (resorption) and new bone is formed (formation), helping maintain the strength and integrity of bones

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Used at 1 mL per day, a 60 mL bottle lasts about 60 days-roughly two months-before youll need a refill