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Acknowledgements This work was supported by the National Key Research and Development Program of China (2024YFC2418800, 2022YFC2504300), the National Natural Science Foundation of China (92468107, 82422045, 82102593, and 82402814), the Capitals Funds for Health Improvement and Research Program by Beijing Municipal Health Commission (2024-2-5052), the Beijing Natural Science Foundation (L256032, 7262117), PLA General Hospital Youth Independent Innovation Science Fund project (22QNFC041), and the China Postdoctoral Science Foundation (XJ2021051)

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Glutathione can provide numerous health benefits, such as: Powerful antioxidant properties: Glutathione helps neutralize free radicals and protects cells from damage [10]

Although gut microbiota dysbiosis in PD is extensively analyzed, its causal mechanisms and the possibilities for intervention still require further research [107, 108] (Fig

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