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When cellular SAM concentrations are low the synthesis of 5-methyltetrahydrofolate by MTHFR will proceed uninhibited, whereas cystathionine -synthase activity will be diminished

Furthermore, a coculture of transgenic overexpressing FGF-2 Schwann cells with dopaminergic neurons improved the survival of dopaminergic neurons and the behavioral outcome in a parkinsonian rat model lesioned with 6-OHDA [134]