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DHA protects hepatocytes from oxidative injury through GPR120/ERK-mediated mitophagy

PMID: 11 CanalesJ.Arenas-MA.MedinaJ.VidalE

That is, mitochondrial signaling dictates macrophage polarization and function and is necessary for responses to activators of innate immune signaling

10.1179/1476830515y.0000000038 [DOI] [PubMed] [Google Scholar] Conde J

The selective inhibitor compound 27 (IPN60090), which is currently in a first-in-class clinical trial, focuses on optimising physicochemical and pharmacokinetic properties, with a strong in vivo target engagement capability, and should strongly inhibit GLS in humans [152, 153]