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These include paracetamol, acetylsalicylic acid or ibuprofen

This is mainly due to the functioning of the pineal gland deteriorating with increased age and a reduction of hormone circadian rhythm amplitude

It also influences epigenetic methylation patterns in animal aging models

Some evidence suggests that the two systems together affect both pleasure-driven eating and energy-driven hunger, which is part of why the CagriSema combination has shown such strong results in trials