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In a mouse study, long-term consumption of a high-sugar diet altered gut microbiota composition, increasing harmful Firmicutes and decreasing beneficial Bacteroidetes, which is associated with gut barrier disruption (Alasmar et al., 2023)

This is further underlined by the detection of GPX3 in ELF following lung injury, both in the mouse model of bleomycin-induced lung fibrosis and in ILD, in particular in HP and sarcoidosis