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*Correspondence: Zhuqi Tang, [email protected]

doi: 10.1016/j.euf.2021.12.002 92 AshtekarAHukDMagnerALa PerleKZhangXPiruatJIet al

While distinct mechanisms such as miRNA regulation and EVs transfer add complexity, these converging pathways collectively sustain a hazardous cycle of microglial activation, oxidative stress, programmed cell death, and chronic inflammation, ultimately driving neurodegeneration in HAND