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Regarding health issues, cancer, respiratory problems, and numerous chronic diseases are caused by chemical pollutants (Kim et al., 2018)

The process starts with molecules that contain heme which is present in the hemoglobin of red blood cells and in other heme proteins such as cytochromes, catalases, peroxidases and tryptophan pyrrolase (11, 12)

NF-kB (nuclear factor-kB) is a transcription factor that regulates many immune and inflammatory response genes.[ref] It can turn up the heat at times when inflammatory cytokines, such as IL-6, IL-13, and TNF-alpha , are needed.[ref] NF-kB also regulates melatonin production in the pineal gland and in cells that produce melatonin

The method for determining the optimal spectral filtering combination for each biochemical parameter and overall in ANN modeling was the same as that used for the PLS regression technique

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