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The maximum decrease (59.9%) was observed under 10 mM concentration of Ca

Mean SD (n =3 biological replicates)

Endoplasmic reticulum stress in the heart: insights into mechanisms and drug targets

Furthermore, they could show that cells lacking both SLC25A39 as well as its paralogue SLC25A40 exhibit defects in the activity and stability of proteins containing ironsulfur clusters (ISCs)

NADPH acts as a cofactor and reducing agent for enzymes such as glutathione reductase and thioredoxin reductase, catalyzing the reduction of glutathione (GSH) and thioredoxin (Trx), respectively (Figure 1)