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Turato G, Di Stefano A, Maestrelli P, Mapp CE, Ruggieri MP, Roggeri A, et al

(24) investigated plasma mtDNA levels in RA patients and found that RA patients had a high sensitivity to mtDNA copy number compared to healthy controls, and also found that plasma mtDNA concentration was significantly correlated with the Disease Activity Score-28-Erythrocyte Sedimentation Rate (DAS28-ESR), which increased with the increase of DAS28-ESR, thus it is reasonable to believe that plasma mtDNA may be an inflammatory contributor as well as a biomarker in RA

Chirgadze et al., 1999

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