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UK Safe intake USA ESADDI (1989) Signs and Symptoms of level (1991) Deficiency1,5,6 Adult men 50400 75250 Decreased uric-acid production and reduced antioxidant protection Adult 50400 75250 women Impaired metabolism of potentially toxic sulfur- containing amino acids (methionine, homocys- Therapeutic dose range teine), which can result in mental disturbances Werbach (1990/99) and, if severe, coma7 Adult men 1002000 Increased sensitivity to sulfites in the environ- Adult 1002000 ment (air pollution) and in the diet (used as women preservatives on salad bars, in dried fruits and wine) Preferred Form and Dosage Schedule Hair loss Fatigue Sodium molybdenate Take with meals, prefer- Possible increased risk of cancer (particularly ably with the dose divided throughout the day cancer of the esophagus) Possible increased risk of kidney stones (xan- thine stones) Minerals and Trace Elements 79 Use in Prevention and Therapy 5

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Subsequently, 38 colonies from each plate were picked for identification