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Also, Pasculli and colleagues suggested that therapies targeting KOA, including those addressing BMLs, produce improvements in pain and function, supporting biological basis for cell-based approaches [37]

Topical formulations require penetration enhancers or vehicle optimization, and in vivo data suggest lower bioavailability compared to subcutaneous administration

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This study only followed patients for 8 weeks

Long-term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDY