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The consensus principle that GHRH and GHS synergize in vivo but not in vitro was explicable by assuming that GHS 1) evokes GHRH release from the brain, 2) opposes inhibition by SRIF both in the hypothalamus and on the pituitary gland, and 3) stimulates pituitary GH release directly and additively with GHRH

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10.1002/adma.201705694 205 ZhangT.LinF.LiuW.LiuY.GuoZ.XiaoC.et al (2021a)