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An adaptogen should ideally: (a) lessen the harm caused by stress

Cocoplum (Chrysobalanus icaco L.) anthocyanins exert anti-inflammatory activity in human colon cancer and non-malignant colon cells

J Immunol (2001) 167(9):54649

Zhang C, Lu Y, Ai Y, Xu X, Zhu S, Zhang B, Tang M, Zhang L, He T (2021) Glabridin liposome ameliorating UVB-induced erythema and leathery skin by suppressing inflammatory cytokine production

Given that the status of these micronutrients in patients with T2DM is already likely to be suboptimal and that these deficiencies are variously associated with diabetic complications such as compromised endothelial, microvascular, vascular and neurological function, 38,43,4649,80,85,9597 it may be appropriate to consider supplementation where appropriate to mitigate these negative impacts of metformin