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PMID: 235 yaKDudaA

5 Role of Epigenetics in Cancer Drug Resistance Epigenetics is the study of heritable phenotypic changes that occur without altering the DNA sequence

The degree of PP2A methylation is subject to changes according to metabolism

Conjugation reactions usually involve metabolite activation by a highenergy intermediate and have been classified into two general types: type I (e.g., glucuronidation and sulfonation), in which an activated conjugating agent combines with substrate to yield the conjugated product, and type II (e.g., amino acid conjugation), in which the substrate is activated and then combined with an amino acid to yield a conjugated product (Hodgson, 2004)

The preliminary conclusions of the paper are twofold