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144 HarelI.ValenzanoD

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Exploring the imbalance of periodontitis immune system from the cellular to molecular level

Prolonged stimulation of exhausted lymphocytes, which demonstrate attenuated effector function and cytokine secretion in nutrient-depleted microenvironments, by antigen presenting cells via HLA class 1 leads to increased cellular exhaustion 88 , which further impairs the capacity of cells to differentiate into memory phenotypes