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Leukocytes from cultures of patients with severe COVID-19 at endpoint A showed hypomethylation of the chr17: 36,090,102 locus, in the 5 UTR region of CCL3 , when compared to the CTRL group ( Figure 4 )

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Disclosures: Hongqin Xu: Nothing to Disclose, Yanhang Gao: Nothing to Disclose 1033 SALIVARY MICROBIOME IS INDEPENDENTLY ASSOCIATED WITH HOSPITALIZATIONS IN A MULTI-CENTER PROSPECTIVE COHORT OF OUTPATIENTS WITH CIRRHOSIS: NACSELD3 EXPERIENCE Jasmohan Bajaj 1 Masoumeh Sikaroodi 2 Marcela Pea Rodrguez 3 Puneeta Tandon 4 Jennifer Lai 5 Jacqueline Oleary 6 Guadalupe Garcia-Tsao 7 Florence Wong 8 Hugo Vargas 9 Scott Biggins 10 Patrick Kamath 11 Brian Bush 12 K Rajender Reddy 13 Patrick Gillevet 2 , 1 Virginia Commonwealth University, 2 George Mason University, 3 Universidad de Guadalajara, 4 University of Alberta, 5 UCSF, 6 Dallas VAMC, 7 Yale University, 8 University of Toronto, 9 Mayo Clinic Arizona, 10 UPMC, 11 Mayo Clinic Rochester, 12 VCU, 13 University of Pennsylvania Background: Inflammation is a main driver of poor outcomes in cirrhosis

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