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Antioxidants can be divided into endogenous antioxidants, such as antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as exogenous antioxidants, which mainly include non-enzymatic antioxidants such as vitamin C, vitamin E, carotenoids, ubiquinone, and flavonoids (110)

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Another paper experimentally activated the GABA A receptor via injection of muscimol into the insula/S2, which reversed hyperactivity in the insula/S2 during cold-stimulation as measured by fMRI and reduced CIPN symptoms in oxaliplatin-treated monkeys (Nagasaka et al., 2017)

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Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology