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Although previous studies have confirmed that traditional Chinese medicine (TCM) can intervene in the progression of CRC at different pathological stages by regulating the Wnt/-catenin signaling pathway ( 2 Overview of the Wnt/-catenin signaling pathway The Wnt/-catenin signaling pathway is structured into four segments: extracellular signaling, membrane-bound fragment, cytoplasmic fragment, and nuclear fractions (Nusse and Clevers, 2017)