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Following extensive burns, persistent activation of the sympathetic nervous system and prolonged elevation of stress hormones can increase resting energy expenditure to approximately 1.52.0 times normal values, accompanied by marked skeletal muscle protein breakdown and loss of lean body mass (3, 1315)

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The activity of NAD-MDH can be calculated by measuring the change of absorbance value at 450 nm

Its opposing roles, i.e., its ability to suppress autophagy in cancer and cardiac disease while enhancing it in neurodegeneration, reveal its complex, tissue-specific regulatory capacity