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Similar content being viewed by others Introduction Astrocytes, a major type of glial cell in the central nervous system (CNS), play a pivotal role in neuronal survival and function

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Third, PA calcification has been linked to hypoxia, in that hypoxia decreases the expression of serine protease granzyme B stored in the granules of T lymphocytes and natural killer cells, which inhibits store-operated calcium channels (SOCCs) as the main source of calcium mineral by attenuating non-canonical Wnt signals in SMCs, thus increasing calcification of the PA (141)

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J Neurosci Res 66:981991 Murthy CR, Rama Rao KV, Bai G, Norenberg MD (2001) Ammonia-induced production of free radicals in primary cultures of rat astrocytes

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Overall, the integration of docking performance with pharmacokinetic evaluation highlights Ginkgo biloba as a promising source of multitarget lead compounds for Alzheimers disease therapy, while reinforcing the complementary neuroprotective value of Mucuna pruriens

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