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Once JNK is activated and phosphorylated in the cytosol, the next mechanistic step for amplification of mitochondrial injury is its translocation to mitochondria, where it binds to the Sab protein on the outer mitochondrial membrane [54,59]

Data post-processing was conducted using R scripts

Results: According to the analysed studies, this comprehensive review provided a recent update on oxidative stress, free radicals and antioxidants and their impact on the pathophysiology of human diseases

Natural compounds such as piperlongumine and cotylenin A exhibit synergistic therapeutic efficacy with SAS, which suggest that the triple combined treatment with piperlongumine, piperlongumine and SAS is highly effective against pancreatic cancer (Kasukabe et al., 2016

Its sensorineural forms lack effective pharmacotherapy available to prevent, cure or restore hearing function