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Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation

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Pathology of retinal pigment epithelium during age-related macular degeneration The RPE, a single layer of polarized cells that is situated between the rods and cones and the choriocapillaris in the outermost portion of the retina, undergoes major pathological changes during AMD progression (24, 25) (Figure 1)